On October 3, 1997, based on the Decree of the Director General of Higher Education, Ministry of Education and Culture of the Republic of Indonesia No. 396/DIKTI/Kep/1997, the Diploma IV Nursing Educator Study Program was established under the Faculty of Medicine, Hasanuddin University. The Diploma IV Nursing Educator Study Program became the forerunner of the Nursing Science Study Program (PSIK). At the time of its establishment, the Diploma IV Nursing Educator Program offered four specializations, namely: Basic Nursing, Medical-Surgical Nursing, Maternity Nursing, and Pediatric Nursing, with most students coming from nursing education institutions and healthcare services in Eastern Indonesia. The program was later expanded to six specializations with the addition of Psychiatric Nursing and Community Nursing. In 2001, the Diploma IV Nursing Educator Program was closed and transformed into the Nursing Science Study Program, Faculty of Medicine, Hasanuddin University (PSIK FK-UNHAS).

The Nursing Science Study Program, Faculty of Medicine, Hasanuddin University (PSIK FK-UNHAS), was established on May 18, 1999, and was the youngest study program within the Faculty of Medicine, Hasanuddin University, with its academic operations beginning in mid-2000. In 2017, specifically on September 8, the Nursing Science Study Program (PSIK) successfully changed its status from a study program into the Faculty of Nursing, as stipulated in the Rector of Hasanuddin University Decree No. 26150/UN4.1/KL.06/2017.

Fakultas Keperawatan Universitas Hasanuddin saat ini memiliki 5 program studi antara lain Program Studi Magister Ilmu Keperawatan, Program Studi Sarjana Keperawatan, Program studi Profesi Ners, Program Studi Fisioterapi, dan Program Studi Profesi Fisioterapi. Dalam penyelenggaraannya Fakultas Keperawatan dituntut untuk berusaha sejajar dan mandiri bersama dengan fakultas lain di lingkungan Unhas sebagai PTNBH.